Semaglutide
If you’ve been taking Ozempic or Wegovy (both of which contain the active ingredient semaglutide), you might wonder, How long can you take semaglutide for weight loss?
You can take semaglutide for weight loss indefinitely. There’s no set cut-off time, as the drug was originally designed as a diabetes medication and intended for long-term use.
If you’re tolerating it well and it’s working for you, you can take semaglutide until you reach your goal weight and then beyond for long-term weight management. This could be for the rest of your life.
Not bad, right?
Below, we’ll share more info on long-term semaglutide use, including how long it takes to start working for weight loss and potential long-term effects.
Reviewed by Craig Primack, MD, FACP, FAAP, FOMA
How Long Can You Take Semaglutide for Weight Loss?
There’s no cut-off for when you need to stop taking semaglutide — you may be able to take it long-term. That goes for whether you’re taking Ozempic, Wegovy, or compounded semaglutide.
Semaglutide was originally developed to help people with type 2 diabetes manage their blood sugar levels. That means it’s intended for long-term (even life-long) use.
If you’re tolerating semaglutide well and it’s helping you lose or manage your weight, you can take it indefinitely. You’ll start on a low dose, gradually increase your dose, and then stay on a semaglutide maintenance dose for weight loss and management.
Studies on Long-Term Wegovy Use
More studies are needed, but long-term Wegovy use appears to be safe.
FYI, Wegovy contains the active ingredient semaglutide and is approved by the U.S. Food and Drug Administration (FDA) for those with obesity or overweight with a weight-related health condition, like high cholesterol, heart disease, or sleep apnea. Ozempic is FDA-approved for type 2 diabetes but sometimes prescribed off-label for weight loss.
A 2022 study found that taking Wegovy for two years was safe and effective.
A more recent 2024 study is currently the longest clinical trial on Wegovy for weight loss. It looked at almost 18,000 participants with excess weight or obesity and cardiovascular disease who took weekly Wegovy injections for four years and made lifestyle changes, like following a reduced-calorie diet and doing more exercise.
Participants lost weight during the first 65 weeks of treatment and then maintained weight loss over the rest of the experiment. The four-year trial didn’t show any new safety concerns.
Why You Might Stop Taking Semaglutide
While there’s no official cut-off point, a few factors could mean you have to stop taking semaglutide injections.
These include:
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If you want to get pregnant
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If you experience troubling side effects
Your prescribing healthcare provider can make sure GLP-1 (glucagon-like peptide-1) receptor agonist drugs are right for you before prescribing them. If not, they can recommend an alternative weight loss drug.
Let your provider know about any changes in your circumstances or if the side effects of semaglutide are bothering you. They may want to adjust your dose or recommend medication to help manage common side effects.
How Long Does It Take for Semaglutide to Work?
How long does semaglutide take to work? This isn’t the straightforward question it sounds like. Everyone is unique, so there’s no set answer or guarantee. When semaglutide works will vary from person to person.
You could notice your weight change within your first few weeks of weight loss treatment. But significant weight loss will generally take longer.
A 2021 study looked at nearly 2,000 adults with excess body weight or obesity who didn’t have diabetes. Participants took once-weekly Wegovy injections or a placebo for 68 weeks and followed healthy lifestyle changes like eating a nutritious diet and increased physical activity.
Participants saw weight loss by the four-week mark, and this continued for the rest of the experiment.
FAQs
Find answers to frequently asked questions about how long you can take semaglutide for weight loss below.
How Long Does Semaglutide Stay in Your System?
Semaglutide can stay in your system for about five to seven weeks. It has a half-life of one week, meaning it takes a week for the amount of semaglutide in your system to decrease by half. Then it’ll take another week to decrease by half again, and so on.
What Are the Risks of Taking Semaglutide Long-Term?
As with any drug, there may be some risks of taking semaglutide long-term. But before you panic, know these risks are rare.
Semaglutide is generally considered a safe drug, and for many, the benefits outweigh any potential long-term risks. A healthcare professional can help make sure semaglutide is safe for you.
Do You Have to Take Semaglutide Forever?
No, you don’t have to take semaglutide for weight loss forever. You can stop if the side effects are unmanageable or when you reach your weight loss goal.
But always let your healthcare provider know before you stop taking semaglutide (or any other medication).
Bear in mind, you may regain some of the weight you lost if you stop Wegovy. So, you don’t have to take semaglutide forever, but you might want to for chronic weight management.
Can I Prevent Weight Gain After Stopping Semaglutide?
You can maintain your weight with a healthy diet and regular exercise. But your appetite, cravings, and food noise (obsessive thoughts about food) might return to the levels you experienced before taking semaglutide. This may lead to increased food intake and weight gain.
After all, obesity is considered a chronic disease, so semaglutide can help you manage it in the long haul. Just like how if you had high blood pressure (hypertension), you wouldn’t necessarily stop taking blood pressure medication once it’s under control.
How Long Do You Stay on Semaglutide for Weight Loss? Final Verdict
So, how long can you take semaglutide for weight loss? Drum roll, please… You can take semaglutide indefinitely.
There’s no official time limit for this GLP-1 receptor agonist drug, so you may be able to continue semaglutide treatment for the rest of your life — if you want.
Here are the key points to remember:
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Semaglutide is designed to be taken long-term. Studies spanning four years show that ongoing Wegovy use is safe. If your body reacts well to it, you might be able to take semaglutide for the rest of your life to help manage your weight.
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You don’t have to take semaglutide forever. You can theoretically take semaglutide forever to lose weight and then maintain a healthy BMI (body mass index), but you don’t have to if you don’t want to. Mindful eating, regular exercise, and other lifestyle interventions can help prevent regaining the weight you’ve lost.
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How long does it take semaglutide to work? It’s different for everyone. Most people see noticeable changes in their body weight after a few weeks.
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How long can you take Wegovy? Perhaps indefinitely. Consider factors determining how long you can take semaglutide. For instance, trying for a baby or developing troubling side effects or a medical condition can affect how long you take this drug.
Related: Ozempic For Weight Loss: How It Works, Side Effects & MoreRelated: Weight Loss Injections: What You Need to Know
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This article originally appeared on ForHers.com and was syndicated by MediaFeed.org.