New research shows excess salt triggers brain inflammation, offering clues to why many hypertension patients don’t respond to standard medicines. (Image: Pexels)
Salt has long been blamed for harming the heart and kidneys by multiple studies, but new research suggests your brain may be paying an even steeper price. Researchers at McGill University, Canada, have found that eating too much salt can inflame the brain and drive up blood pressure, a finding that challenges decades of medical belief.
For millions struggling with hypertension, particularly those who don’t respond to common drugs, this study offers fresh hope.
In the experiment, rats were fed a salt-heavy diet, similar to meals with instant noodles, bacon, and processed cheese. Instead of only straining the kidneys, the salt set off tiny immune cells in the brain, creating inflammation and releasing a hormone called vasopressin, which pushed their blood pressure higher.
“This is new evidence that high blood pressure can originate in the brain,” says lead researcher Dr. Masha Prager-Khoutorsky, adding that this opens the door to treatments that target the brain directly, not just the heart or kidneys.
High blood pressure, or hypertension, affects two-thirds of people over 60 and is behind an estimated 10 million deaths worldwide each year. Often symptomless, it’s a dangerous gateway to heart disease, stroke, and kidney failure. Yet, about one in three patients don’t respond well to standard medicines, leaving doctors searching for answers. The brain connection may explain why. If salt can rewire how the brain controls blood pressure, then drugs aimed only at blood vessels and kidneys may miss the real source of the problem.
Why it matters in daily life
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The salt given to rats were similar to what many consume in a fast-food-heavy diet. That makes the research all the more urgent for countries like India, where salty packaged snacks and instant meals are part of daily life.
The McGill team is now testing if the same brain-based process happens in humans. If proven, doctors may soon have new treatments that calm brain inflammation, offering relief to millions whose blood pressure refuses to come down. As Dr. Prager-Khoutorsky puts it: “The brain’s role in hypertension has largely been overlooked. With new tools, we’re finally able to see these changes in action.”
Disclaimer: This article, including health and fitness advice, only provides generic information. Don’t treat it as a substitute for qualified medical opinion. Always consult a specialist for a specific health diagnosis.